Search results for " CRH"
showing 2 items of 2 documents
Ethanol releases corticotropic releasing hormone (CRH) from rat hypothalamic explants; role of acetaldehyde
2009
Ethanol activates hypothalamic-pituitary-adrenal (HPA) axis, resulting in adrenocorticotropic hormone (ACTH) glucocorticoid release, and a modification of the response of this axis to other stressors (Lee et al 1999, 2000). To determine the mechanisms responsible for these effects we investigated : 1) whether ethanol was able to release CRH from incubated hypothalamic explants; 2) whether acetaldehyde (ACD), its first metabolite formed in the brain by catalase activity, might play a role in ethanol effects. To this aim, rat hypothalamic explants were incubated with: 1) medium containing ethanol at 150 mg %; 2) different concentrations of ACD (4.4, 13.2, 44, 132 x 10-3 mg%); 3) ethanol plus …
Ethanol Modulates Corticotropin Releasing Hormone Release From the Rat Hypothalamus: Does Acetaldehyde Play a Role?
2010
BACKGROUND AND METHODS Ethanol (EtOH) activates hypothalamic-pituitary-adrenal (HPA) axis, resulting in adrenocorticotropin hormone, glucocorticoid release, and in modifications of the response of the axis to other stressors. The initial site of EtOH action within the HPA system seems to be the hypothalamus. Thus, to determine the mechanisms responsible for these effects, we investigated: (i) whether EtOH was able to release corticotrophic releasing hormone (CRH) from incubated hypothalamic explants; (ii) whether acetaldehyde (ACD), its first metabolite formed in the brain by catalase activity, might play a role in EtOH activity. To this aim, rat hypothalamic explants were incubated with: (…